Paolo Bernardi Selected Research

Cyclophilins (Cyclophilin)

10/2014	NIM811, a cyclophilin inhibitor without immunosuppressive activity, is beneficial in collagen VI congenital muscular dystrophy models.
1/2014	Melanocytes from Patients Affected by Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy have Dysfunctional Mitochondria That Can be Rescued with Cyclophilin Inhibitors.
1/2010	Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.
6/2009	Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice.
2/2009	Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury.
5/2007	Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
5/2006	Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole.

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Paolo Bernardi Research Topics

Disease

18	Neoplasms (Cancer) 05/2022 - 08/2003
16	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 04/2002
14	Scleroatonic muscular dystrophy 12/2021 - 12/2003
13	Muscular Diseases (Myopathy) 04/2016 - 04/2002
11	Bethlem myopathy 12/2021 - 12/2003
9	Muscular Dystrophies (Muscular Dystrophy) 10/2019 - 12/2008
3	Colonic Neoplasms (Colon Cancer) 01/2020 - 08/2002
3	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2018 - 01/2009
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2017 - 06/2013
3	T-Cell Leukemia (Leukemia, T Cell) 07/2009 - 09/2002
2	Contracture 01/2022 - 10/2008
2	Heart Diseases (Heart Disease) 01/2020 - 07/2011
2	Ischemia 01/2020 - 01/2015
2	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2018 - 01/2018
2	Inborn Genetic Diseases (Disease, Hereditary) 04/2016 - 04/2008
2	Myocardial Infarction 01/2016 - 06/2014
2	Carcinoma (Carcinomatosis) 11/2014 - 01/2014
2	Reperfusion Injury 06/2014 - 05/2014
2	Liver Neoplasms (Liver Cancer) 05/2014 - 02/2014
2	Carcinogenesis 06/2013 - 01/2005
2	Inflammation (Inflammations) 09/2011 - 08/2004
2	Necrosis 09/2011 - 03/2009
2	Prostatic Neoplasms (Prostate Cancer) 05/2009 - 08/2002
1	Hemorrhage 12/2021
1	Neuroinflammatory Diseases 11/2020
1	Paraplegia (Spastic Paraplegia) 11/2020
1	Hereditary Spastic Paraplegia 11/2020
1	Neoplasm Metastasis (Metastasis) 04/2020
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Parkinson Disease (Parkinson's Disease) 11/2018
1	Pain (Aches) 03/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Huntington Disease (Huntington's Disease) 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 01/2018
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2018
1	Neurofibromatoses (Neurofibromatosis) 01/2017
1	Sarcopenia 01/2014

Drug/Important Bio-Agent (IBA)

19	CollagenIBA 12/2021 - 12/2003
13	Mitochondrial Permeability Transition PoreIBA 01/2020 - 05/2007
11	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2002
9	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2016 - 01/2007
7	Adenosine Triphosphate (ATP)IBA 05/2022 - 05/2006
7	Extracellular Matrix ProteinsIBA 10/2014 - 04/2008
7	Cyclophilins (Cyclophilin)IBA 10/2014 - 05/2006
3	Ion Channels (Ion Channel)IBA 01/2020 - 04/2008
3	Pharmaceutical PreparationsIBA 01/2020 - 06/2009
3	EndotoxinsIBA 11/2018 - 08/2003
3	AntioxidantsIBA 01/2018 - 03/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2015 - 07/2009
3	OligomycinsIBA 01/2014 - 12/2003
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2020 - 06/2014
2	idebenoneIBA 01/2018 - 02/2012
2	(melle-4)cyclosporinIBA 10/2014 - 01/2014
2	LigandsIBA 05/2014 - 04/2006
2	GalactosamineIBA 09/2011 - 08/2003
2	LipopolysaccharidesIBA 09/2011 - 08/2003
2	Arachidonic Acid (Vitamin F)IBA 01/2010 - 08/2002
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 08/2004 - 08/2003
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 08/2004 - 08/2003
1	SiliconesIBA 01/2022
1	Caspase 8 (Caspase-8)IBA 04/2021
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 11/2020
1	Bz-423IBA 11/2020
1	BenzodiazepinesIBA 11/2020
1	OzoneIBA 04/2020
1	Peptides (Polypeptides)IBA 01/2020
1	HexokinaseIBA 01/2020
1	IsoxazolesIBA 10/2019
1	Dopamine (Intropin)FDA LinkGeneric 11/2018
1	QuinonesIBA 11/2018
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 02/2018
1	NAD (NADH)IBA 01/2018
1	Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)IBA 01/2018
1	Coenzymes (Enzyme Cofactors)IBA 01/2018
1	alisporivirIBA 11/2017
1	Neurofibromin 1 (Neurofibromin)IBA 01/2017
1	ras ProteinsIBA 01/2017
1	RNA (Ribonucleic Acid)IBA 04/2016
1	N- (3- chloro- 2- methylphenyl)- 5- (4- fluoro- 3- hydroxyphenyl)isoxazole- 3- carboxamideIBA 10/2015
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2014
1	respiratory complex IIIBA 12/2014
1	ProteomeIBA 12/2014
1	Protease La (Endopeptidase La)IBA 12/2014
1	AnilidesIBA 06/2014
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 05/2014
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 05/2014
1	Transforming Growth Factor beta (TGF-beta)IBA 02/2014
1	SerpinsIBA 02/2014
1	Succinic Acid (Succinate)IBA 06/2013
1	Transcription Factors (Transcription Factor)IBA 06/2013
1	Antineoplastic Agents (Antineoplastics)IBA 06/2013

Therapy/Procedure

12	Therapeutics 11/2020 - 01/2005
1	Operative Surgical Procedures 01/2022
1	Mammaplasty (Breast Reconstruction) 01/2022
1	Mastectomy (Mammectomy) 01/2022
1	Ligation 11/2014
1	Induced Hyperthermia (Thermotherapy) 01/2014
1	Precision Medicine 01/2014